中国比较医学杂志2013，Vol.23Issue(3)：34-38,后插3,6.DOI:10.3969/j.issn.1671.7856.2013.03.009
丹酚酸A对实验性肺纤维化大鼠的保护作用研究
Protection effect of Salvianolic acid A on pulmonary fibrosis of rat
摘要
Abstract
Objective Investigate the effects of salvianolic acid A on rats of bleomycin -induced pulmonary fibrosis and potential mechanisms. Methods Single-dose bleomycin was given via intratracheal on Day 0 and rats were treated from Dayl daily with tail-vein injection of salvianolic acid A for 28 d. Record weights and observe general physical sign. Measure free radical ..pulmonary function and take electron microscopes. Results Salvianolic acid A could recover physical sign, enhance SOD and MDA activities and reduce MDA contents. Salvianolic acid A could minimize of alveolar spaces and alleviate the inflammation. Moreover, it could improve pulmonary function and decrease collagen expression, inhibits type Ⅱ alveolar epithelial cells hyperplasia in pulmonary fibrosis rats. Conclusion Salvianolic acid A could attenuate the bleomycin induced pulmonary fibrosis of rats and potential mechanism may be correlated with antioxidation of SAA.关键词
丹酚酸A/肺纤维化/抗氧化/保护Key words
Salvianolic acid A/ Pulmonary fibrosis/ Antioxidant/ Protection分类
医药卫生引用本文复制引用
孔勤,刘瑞敏,寿旗扬,肖颖,朱科燕,陈民利..丹酚酸A对实验性肺纤维化大鼠的保护作用研究[J].中国比较医学杂志,2013,23(3):34-38,后插3,6.基金项目
浙江省卫生高层次创新人才培养工程项目. （）
