中国比较医学杂志2013，Vol.23Issue(3)：39-41,3.DOI:10.3969/j.issn.1671.7856.2013.03.010
恒河猴脊髓半断模型行脑和脊髓fMRI检查麻醉方案的实验研究
Experimental study of continuous intravenous anesthesia for fMRI of Rhesus monkey
田肇隆 1王小华 1许亚超 1李晓光 1饶家声 1赵璨1
作者信息
摘要
Abstract
Objective Provide a simple, convenient, and safe manipulation condition to fMRI animal experiments that require sustained anesthesia. This investigation was designed to confirm the appropriate anesthetic regimen for fMRI experiment of rhesus. Method Seven rhesus from Academy of Military Medical Sciences are female, weight 4 ~ 7 kg using continuous intravenous anesthesia ( ketamine + propofol). Ketamine 10mg/kg im until the rhesus sleep then establish a continuous intravenous access, continuous injected propofol 0. 3mg/kg/min, then intermittent ketamine1mg/ kg/30min. The rhesus placed in a special experiment rack and the incisor hold up to keep the airway open. During the whole test we monitored breathing, heart rate, corneal reflex and pupil. Results 44 times experiments successfully completed, no animal have restlessness, respiratory depression, arrhythmia, deaths and other serious complications. At the end of the experiment, the experimental animals awake soon. Conclusion continuous intravenous anesthetic of propofol and ketamine could provide more secure, convenient and practical method for fMRI animal experiments.关键词
恒河猴/功能磁共振/全凭静脉麻醉Key words
Rhesus monkeys/ Functional magnetic resonance/ Intravenous anesthesia.分类
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田肇隆,王小华,许亚超,李晓光,饶家声,赵璨..恒河猴脊髓半断模型行脑和脊髓fMRI检查麻醉方案的实验研究[J].中国比较医学杂志,2013,23(3):39-41,3.
