中国实用妇科与产科杂志2013，Vol.29Issue(5)：364-367,4.
胎盘蛋白14在子宫内膜异位症发病中的作用
The primary study on role of placental protein 14 in pathogenesis of endometriosis
摘要
Abstract
Objective To approach primarily the role of placental protein 14 (PP14) in the pathogenesis of endometriosis by detection of the PP14 levels in peritoneal fluid (PF) and serum, and PP14 expression in endometriotic lesions in women with endometriosis. Methods The levels of PP14 and CA125 in PF and serum from 75 women with ovarian endometriosis and 49 women without endometriosis were determined with ELISA, and PPM expression in endometriotic lesions were detected by immunohistochemical staining. Results The concentrations of PP14 and CA125 in serum were both significantly higher in women with endometriosis than those in women without endometriosis ( P < 0. 05 ). After GnRHa therapy, the concentrations of PPM and CA125 in serum were also significantly decreased in women with endometriosis (P<0. 05). However, the concentrations of PP14 or CA125 in PF did not show significant difference between women with and without endometriosis (P>0. 05). PP14 expression could be detected, respectively, in 84% of ovarian endometriotic lesions, in 6% of eutopic endometrial tissues of women with endometriosis, and in 5% of control endometrial tissues. Conclusion PP14 may play a role in the pathogenesis of endometriosis, and may also be used as a marker for monitoring the therapeutic effects of the disease.关键词
子宫内膜异位症/胎盘蛋白14/癌抗原125/血清/腹腔液Key words
endometriosis/placental protein 14/CA125 /serum/peritoneal fluid分类
医药卫生引用本文复制引用
王萍,朱丽波,苏琴芬,张信美..胎盘蛋白14在子宫内膜异位症发病中的作用[J].中国实用妇科与产科杂志,2013,29(5):364-367,4.基金项目
国家自然基金(81270672) （81270672）
浙江省自然基金(Y2110181,Y2110128) （Y2110181,Y2110128）
上海市浦江人才计划基金(10PJ1409000) （10PJ1409000）
