中国实用妇科与产科杂志2013，Vol.29Issue(5)：371-374,4.
儿童卵巢恶性生殖细胞肿瘤17例临床分析
The diagnosis and treatment of malignant ovarian germ cell tumor in children :a clinical study of 17 patients
摘要
Abstract
Objective To investigate the clinical characteristics, treatment experience of malignant ovarian germ cell tumor in children. Methods Seventeen malignant ovarian germ cell tumor (MOGCT) patients under 14 years old, who were diagnosed and treated in Shengjing Hospital Affiliated to China Medical University between June 2003 and June 2012. A retrospective analysis was conducted on the clinical data of them. Results The seventeen children were all got the final diagnosis by operation, histologically, ovarian yolk sac tumors (n = 10) were found most frequently,followed by dysgerminoma ( n = 3 ) , immature ovarian teratomas ( n = 2 ) , embryonal carcinoma ( n = 1) and a special case that yolk sac tumor in one ovary and dysgerminoma in the other. Patients were mostly treated with fertility preservation surgery ( n = 14) ,including 5 in stage I a ( FIGO) , 6 in stage I c ( FIGO) , 1 in stage II ( FIGO) , 1 in stage I ( FIGO) and 1 in stage IV (FIGO). Three children were treated by cytoreductive surgery, including one in stage I ,one in stage IIIc and the other in stage IV- Eleven patients received chemotherapy and one received radiotherapy after operation. During a follow-up of 8 ~ 96 months, there are 2 death cases, 2 lost cases and one case experienced recurrence. The rest children are healthy. Conclusion The operation method of malignant ovarian germ cell tumor in children should take more consideration in fertility preservation. The lesser degrees of surgical staging would be recommended, especially in early stage.关键词
儿童/卵巢恶性生殖细胞肿瘤Key words
children/ malignant ovarian germ cell tumor分类
医药卫生引用本文复制引用
张丹晔,谭明子,王慧敏,李潇,高一平,郭瑞江,林蓓..儿童卵巢恶性生殖细胞肿瘤17例临床分析[J].中国实用妇科与产科杂志,2013,29(5):371-374,4.基金项目
盛京自由研究者计划(200807) （200807）
辽宁省教育厅重点实验室(2008S247) （2008S247）
