摘要
Abstract
OBJECTIVE: To explore the effects of Qili qiangxin capsule on myocardial fibrosis and expression of connective tissue growth factor (CTGF) in rats with chronic heart failure (CHF). METHODS: CHF model was induced by partially banding abdominal aortic artery. Model rats were divided into sham-operation group (constant volume of normal saline), model group (constant volume of normal saline), enalapril group (10 mg/kg), Qili qiangxin capsule high-dose, medium-dose and low-dose groups (1, 0.5, 0.25 mg/kg). They were given medicine once a day for consecutive 4 weeks.Hemodynamic parameters and left ventricular weight index (LVMI) were detected, Picric-Sinus Red (PSR) Polarimetry was used to observe collagen morphology in left ventricular interstitial tissue, measure collagen volume fraction (CVF); the expression of CTGF in left ventricular tissue was evaluated by immunohistochemical staining and Western blot analysis. RESULTS: Compared with model group, LVMI, CVF and CTGF protein expression of Qili qiangxin capsule high-dose, medium-dose and low-dose groups decreased significantly (P<0.01 or P<0.05). LVEDP, Ⅰ CVF/ⅢCVF of high-dose and medium-dose groups decreased significantly (P<0.01); -dp/dtmax increased significantly (P<0.05) ; pathological morphology was improved. + dp/dtmax of high-dose group increased significantly (P<0.01 or P<0.05). CONCLUSIONS: Qiliqiangxin capsule attenuates ventricular hypertrophy in CHF rats, inhibits MF and improves cardiac function, which is dependent on its effect on expressions of CTGF in left ventricular tissue.关键词
芪苈强心胶囊/慢性心力衰竭/结缔组织生长因子/心肌纤维化Key words
Qili qiangxin capsule/ Chronic heart failure/ Connective tissue growth factor/ Myocardial fibrosis分类
医药卫生
