摘要
Abstract
OBJECTIVE: To study prevetion and treatment effects of Astaragali Radix and Angelica sinensis decoction on acute renal injury in rats and its mechanism. METHODS: Acute kidney injury (acute renal injury, AKI) model was induced by left and right kidney occlusion-reperfusion. Rats were divided into sham operation (constant volume of normal saline), model group (constant volume of normal saline), Astaragali Radix and A. sinensis decoction high-dose, medium-dose and low-dose groups (18, 9, 4.5 g/kg). They were given medicine intragastrically 7d before operation, once a day, for continuous 7d, 30 min after reperfusion by gavage for 1 time. 24 h after reperfusion, the contents of Scr and BUN were determined, and the contents of MDA and GSH, the activity of SOD in renal tissue homogenate were also determined. Renal tubular injury score were calculated. RESULTS: Compared with sham operation group, the contents of Scr and BUN in rat serum increased significantly and the content of MDA also increased significantly, while the content of GSH and the activities of SOD decreased significantly. The renal tubular injury score increased significantly (P<0.01). Compared with model group, the contents of Scr and BUN in Astaragali Radix and A. sinensis decoction high-dose and medium-dose groups decreased significantly, and the content of MDA also decreased significantly; SOD activity increased significantly; renal tubular injury score decreased significantly(P<0.01 or P<0.05). CONCLUSION: The effects of Astaragali Radix and A. sinensis decoction on acute renal injury in rats may be related to the improvement of renal tubular function and regulation of antioxidant factor.关键词
缺血再灌注/血清肌酐/尿素氮/肾小管损伤指数Key words
Ischemia reperfusion/ Serum creatinine/ BUN/ Renal tubular injury index分类
医药卫生
