中国药房2013，Vol.24Issue(11)：993-995,3.DOI:10.6039/j.issn.1001-0408.2013.11.12
星点设计-响应面法优选身痛逐瘀胶囊中药材的提取工艺
Optimization of Extraction Technology of Chinese Medicinal Material from Shentong Zhuyu Capsules by Central Composite Design and Response Surface Methodology
摘要
Abstract
OBJECTIVE: To optimize the extraction technology of Chinese medicinal material from Shentong zhuyu capsules. METHODS: The extraction technology was optimized by central composite design and response surface methodology with ethanol concentration, ratio of material to liquid and extraction time as factors using the contents of ferulic acid, liquiritin and hydroxysaf-flor yellow A as index. RESULTS: The optimum technology was as follows: ethanol concentration of 49% , liquid-material ratio of 1 : 13.7 (m/V) and extraction time 156 min. The predicted value of the total content of ferulic acid, liquiritin and hydroxysafflor yellow A was 88.21 mg/g under this condition, which was in line with Results of trial(87.69 mg/g). CONCLUSION: The method is simple, reasonable and highly predictive.关键词
身痛逐瘀胶囊/星点设计-响应面法/提取工艺Key words
Shentong zhuyu capsules/ Central composite design and response surface methodology/ Extraction technology分类
医药卫生引用本文复制引用
马丁,阮洪生,刘树民..星点设计-响应面法优选身痛逐瘀胶囊中药材的提取工艺[J].中国药房,2013,24(11):993-995,3.
