中国药房2013，Vol.24Issue(12)：1079-1082,4.DOI:10.6039/j.issn.1001-0408.2013.12.08
依那普利治疗原发性高血压的疗效与安全性的系统评价
Systematic Review of Therapeutic Efficacy and Safety of Enalapril in the Treatment of Essential Hypertension
摘要
Abstract
OBJECTIVE: To evaluate therapeutic efficacy and safety of enalapril in the treatment of essential hypertension. METHODS: Retrieved from Pubmed, EMbase, ISI, CBM, CNKI , VIP, Wanfang database and The Cochrane Library, randomized controlled trials (RCTs) about enalapril in the treatment of essential hypertension were collected. The qualities of included studies were evaluated by Cochrane library 5.0. Rev Man 5.0 software was used to carry out Meta-analysis of homogeneous studies. RESULTS: 18 RCTs were included, involving 3 088 patients. Compared with placebo, enalapril significantly reduced systolic blood pressure [MD=-7.21, 95%CI(-8.79, -5.64), P<0.01] and diastolic pressure [MD=-4.07, 95%CI(-5.03, -3.11), P<0.01], the differences were statistically significant; there was statistical significance in effective rate between enalapril group and placebo group[OR=2.51, 95%CI(1.74, 3.60), P<0.01]. There was no statistical significance in the incidence of ADR between enalapril group and placebo group [OR=1.22, 95%CI(0.95, 1.56),P>0.05]. CONCLUSION: Enalapril can significantly lower blood pressure with good security, while more research is needed to confirm.关键词
依那普利/原发性高血压/随机对照试验/系统评价Key words
Enalapril/ Essential hypertension/ Randomized controlled trial/ Systematic review分类
医药卫生引用本文复制引用
邹雅敏,董卫华,董亚琳..依那普利治疗原发性高血压的疗效与安全性的系统评价[J].中国药房,2013,24(12):1079-1082,4.基金项目
国家"十一五"科技支撑计划重点项目(No.2009BAI76B030219) （No.2009BAI76B030219）
