摘要
Abstract
OBJECTIVE: To study the influence of acarbose on the blood lipids of patients with type 2 diabetes through Me-ta-analysis. METHODS: Related documents were retrieved from Pubmed, Elsevier, Springer, Wanfang database, CNKI, etc. Their publishing dates ranged from Jan. 1996 to Jul. 2012. The qualities of literatures were evaluated by two authors with Cochrane evaluation booklet, and Rev Man 5.0 software was used for Meta-analysis. RESULTS: 14 RCT involving 1 127 patients were included. Meta-analysis showed that compared with control group, acarbose could reduce the levels of TC [SMD= -0.17, 95% CI (-0.32, -0.03), P=0.02] and TG [SMD=-0.24, 95%CI(-0.37,-0.11), P<0.01] while decreased HDL-C level [SMD= 0.24, 95%CI(0.09,0.40), P<0.01]. There was no statistical significance in LDL-C between 2 groups [SMD=-0.11, 95%CI (-0.57,0.35), P=0.54]. CONCLUSION: The long-term administration of acarbose will make a significant decrease of TC and TG levels in type 2 diabetes patient while make a significant increase of the HDL-C. It shows no significant effect on LDL-C.关键词
阿卡波糖/荟萃分析/2型糖尿病/血脂Key words
Acarbose/ Meta-analysis/ Type 2 diabetes/ Blood lipid分类
医药卫生
