中国医科大学学报2013，Vol.42Issue(1)：35-37,3.
系统性红斑狼疮患者尿N-乙酰-β-氨基葡萄糖苷酶水平及其临床意义的研究
The Level of Urinary N-acetyl-β-D-glucosaminidase in Systemic Lupus Erythematosus Patients
摘要
Abstract
Objective To explore the level of N-acetyl-β-glucosaminidase (NAG) and its clinical significance in patients with systemic lupus erythematosus (SLE). Methods According to the results of urine micro-protein, sixty -five patients with SLE were recruited and divided into simple tubular involvement group (n =30) and renal tubular as well as glomerular involvement group (n =35). There was no patient with simple glomerular involvement. Twenty-one age- and sex-matched healthy individuals were enrolled as control. NAG was detected by scattering turbidimetry and colorimetry. Results The levels of urinary NAG were significantly higher in the simple tubular involvement group and renal tubular as well as glomerular involvement group compared with the control group (P < 0.05). There was no significant difference between the simple tubular involvement group and renal tubular as well as glomerular involvement. Positive correlation was found between urinary NAG and urinary β2-micro-globulin in 65 patients (r =0.96, P < 0.01). Conclusion Renal tubular lesions can exist alone in patients with lupus nephritis. Urinary NAG is a useful marker for the detection of renal involvement in lupus nephritis.关键词
系统性红斑狼疮/N-乙酰-β-氨基葡萄糖苷酶/β2-微球蛋白Key words
systemic lupus erythematosus/ N-acetyl-β-glucosaminidase/ β2-microglobulin分类
医药卫生引用本文复制引用
赵珊,孙婷婷,李羽佳,吴可非,田百玲,刘旭东,赵萌萌,杨娉婷,肖卫国..系统性红斑狼疮患者尿N-乙酰-β-氨基葡萄糖苷酶水平及其临床意义的研究[J].中国医科大学学报,2013,42(1):35-37,3.基金项目
国家自然科学基金资助项目(81271324) （81271324）
辽宁省自然科学基金资助项目(201202250) （201202250）
辽宁省医学高峰建设工程重点科研项目(200932 （）
2010006) （）
