中国药理学通报2013，Vol.29Issue(5)：597-600,4.DOI:10.3969/j.issn.1001-1978.2013.05.002
抑癌基因PTEN与肿瘤血管生成研究进展
Review of PTEN in tumor angiogenesis
摘要
Abstract
PTEN is a tumor suppressing gene with phosphatase activity. It is one of the members of the dual specificity protein phosphatase family ( DSPs ). And it has both lipid phosphatase and protein tyrosine phosphatase activity. In the process of tumor proliferation, invasion and migration, increasing attentions have been directed towards tumor angiogenesis as a key factor in tu-morigenesis. Tumor suppressing gene PTEN regulates expression of HIF-1, MMPs, VEGF, NHERF-1 and other angiogenesis-re-lated signals and oxidative product by affecting the PI3K/Akt signaling pathway, which further impacts tumor angiogenesis. This article reviews the current research status based on the relationship between PTEN and tumor angiogenesis.关键词
抑癌基因/PTEN/肿瘤/血管生成/PI3K/AktKey words
tumor suppressor gene/ PTEN/ tumor/ angiogenesis/ PDK/ Akt分类
医药卫生引用本文复制引用
沈存思,范方田,陶丽,陈文显,王爱云,陆茵..抑癌基因PTEN与肿瘤血管生成研究进展[J].中国药理学通报,2013,29(5):597-600,4.基金项目
国家自然科学基金资助项目(No 81173174 81202655) （No 81173174 81202655）
江苏省自然科学基金资助项目(No BK2010085) （No BK2010085）
十一五科技支撑计划(No 2008BAI51B02) （No 2008BAI51B02）
教育部博士点基金(No 20113237110008) （No 20113237110008）
江苏省国际合作项目(No SBZ200900175),江苏省教育厅重大专项(No 09KJA360002) （No SBZ200900175）
江苏省中药药效与安全性评价重点实验室开放课题(P09013) （P09013）
江苏高校优势学科建设工程资助项目(PAPD).江苏省普通高校研究生科研创新计划项目(No CXZZ12-0622) （PAPD）
