郑州大学学报（理学版）2013，Vol.45Issue(1)：77-80,4.DOI:10.3969/j.issn/1671-6841.2013.01.019
大鼠灌胃冬凌草乙素的药代动力学研究
Pharmacokinetic Study of Ponicidin in Rats by Gavage
摘要
Abstract
An HPLC method was established for the determination of ponicidin in plasma of rats and the pharmacokinetics of ponicidin in rats were studied. Rats were given 20 mg/kg ponicidin, and blood samples were collected at different time. After i. g. administration, drug plasma concentration was determined by HPLC, and pharmacokinetic parameters were calculated. The method was linear over the range of 50 ~ 5 000 μg/L( r = 0. 998 1) . The recovery of ponicidin in rat plasma was more than 80% . Both in-tra-day RSD and inter-day RSD were less than 15%. After i. g. administration of ponicidin, the major pharmacokinetic parameters AUC0-t, AUCt-∞ , ke, T1/2, CL/F, Cmax and Tmax were (9.85 ±2.89) mg · h/L, (11.81 ±3.45) mg · h/L, (0. 11 ±0.04) h-1, (3.52 ±1. 16) h, (1.08 ±0. 10) L/(kg · h), (3.07 ±2.30) μg/L and (0.67 ±0.33) h, respectively. The method was sensitive, precise and accurate. It could be applied in the pharmacokinetic study of ponicidin in rats. It was concluded that ponicidin could be eliminated fast without obviously accumulation in rats.关键词
冬凌草乙素/高效液相色谱法/药代动力学Key words
ponicidin/ high performance liquid chromatography/ pharmacokinetics分类
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杜鹏强,李晓天,石迎迎,于彤..大鼠灌胃冬凌草乙素的药代动力学研究[J].郑州大学学报（理学版）,2013,45(1):77-80,4.
