实验动物与比较医学2013，Vol.33Issue(2)：117-120,4.DOI:10.3969/j.issn.1674-5817.2013.02.007
经颅注射无水乙醇建立大鼠脑损伤模型初步探讨
Transcranial Injection of Ethanol for Establishing Brain Injury Model in Rat
摘要
Abstract
Objective To establish a stable rat model of brain injury. Methods Ten Rats were transcranially injected with ethanol. Results The success rate of rat brain injury model is 100%, and 10 sham-operated rats survived too. After four weeks experimental group and sham group was no significant difference in body weight and daily food intake. (376.1 ± 11.5 g vs 353.2 ± 10.3 g; P=1.534); (23.4 ± 3.1 g vs 19.8 ± 2.3 g; P=0.723). By brain magnetic resonance imaging, pathology HE staining, and brain tissue slices TTC staining can confirm modeling success. Conclusion Transcranial injection of ethanol to establish rat brain injury model is simple. Success rate is higher than traditional methods. A solid foundation is established for further studies on brain injury.关键词
脑损伤/模型/大鼠Key words
Brain injury/ Model/ Rat分类
生物科学引用本文复制引用
贺继刚,沈振亚,滕小梅,丁英龙..经颅注射无水乙醇建立大鼠脑损伤模型初步探讨[J].实验动物与比较医学,2013,33(2):117-120,4.基金项目
"苏州市应用基础研究计划项目"编号SYS201229 （）
"江苏省医学重点学科"编号XK201118 （）
