现代检验医学杂志2013，Vol.28Issue(2)：48-50,3.DOI:10.3969/j.issn.1671-7414.2013.02.013
抗核抗体滴度与IgG,C3,C4水平及抗ENA抗体结果的相关性
Relationship between Human Immunoglobulin and Complement andthe Positive Results of Different Items in the Anti-extractable Nuclear Antigen with the Titer of Antinuclear Antibodies
摘要
Abstract
Objective To explore the relationship between immunoglobulin G(IgG) and complement 3 (C3) and C4 with the titer of antinuclear antibodies (ANA) ,and to investigate the correlation between the positive results of different items in the anti-extractable nuclear antigen (anti-ENA) with the titer of ANA.Methods The author analysed the results of autoimmune detection of 1813 patients from May 2010 to June 2012.ANA were tested by indirect immunofluorescence method,anti-ENA antibody were tested by ELISA method,IgG and C3,C4 were determined by immunoturbidimetry.According to the different titers,the patients were divided into several groups,the titer of ANA=1:100 as group l,the titer of ANA=1: 160 as group 2,the titer of ANA=1:320 as group 3,the titer of ANA=1:640 as group 4,the titer of ANA=1:1 280 as group 5,the titer of ANA=1:3 200 as group 6, the titer of ANA>3 200 as group 7,120 cases randomly selected from ANA<1:100 group as group 8(negative group).The change of IgG and complement as well as the positive rates of the specific antibodies of anti-ENA were analyzed by SPSS17.0 software.Results When the titer of ANA≥1:100,the levels of IgG were obviously higher than that in the negative group (F=31.19, P<0.05).When the titer of ANA≥1:320, the levels of C3 and C4 were lower than that in the negative group(F=42.15,9.57,P<0.05).Overall anti-ENA positive rates increased significantly with the titer of ANA (χ2=86.67, P<0.05) ,and the positive rates of various antibodies were different.Anti-SSA and anti-SSB were the most frequent at ANA titers of 1 : 100 to 1 : 3 200,while anti-U1RNP were the most frequent at ANA titers of 1:3 200.Conclusion IgG and C3,C4 were related to the titer of ANA.The positive rates of the overall anti-ENA and some specific antibodies of anti-ENA were related to the titer of ANA.The clinician should pay attention to the value of ANA titer in autoimmune disease diagnosis.关键词
抗核抗体/免疫球蛋白/补体/抗可提取的核抗原(ENA)抗体Key words
antinuclear antibodies/ immunoglobulin/ complement/ anti-ENA分类
医药卫生引用本文复制引用
舒颖,张平安,魏新素,叶芳丽,周心房..抗核抗体滴度与IgG,C3,C4水平及抗ENA抗体结果的相关性[J].现代检验医学杂志,2013,28(2):48-50,3.基金项目
国家临床重点专科建设项目资助[财社(2010)305号]. （2010）
