现代检验医学杂志2013，Vol.28Issue(2)：63-65,3.DOI:10.3969/j.issn.1671-7414.2013.02.018
非小细胞肺癌中BCRP mRNA表达的临床意义
Expression and Clinical Significance of BCRP in NSCLC
吴玉竹 1骆海军 2王鹏 1刘跃1
作者信息
- 1. 湖北医药学院附属太和医院检验部,湖北十堰,442000
- 2. 贵阳医学院,贵阳,550000
- 折叠
摘要
Abstract
Objective To investigate the expression and evaluate clinical significances of breast cancer resistance protein (BCRP) in non-small cell lung cancer (NSCLC).Methods Collected fresh lung cancer of 47 cases (exprement group), 14 cases of normal lung tissue(control group) from April 2010 to June 2010.Real-time PCR method was used to detect the expression levels of BCRP mRNA in 14 normal tissues and 47 NSCLC cases.Results The expression of BCRP mRNA were 0.59±0.26 in NSCLC and 0.19±0.17 in normal lung tissues.The expressions of BCRP,GST-π in NSCLC were higher than those in normal tissues (t=6.74,P<0.001).The expression of BCRP were not correlated with age, sex, histological types and clinical stage (t=0.29~1.53, P> 0.05).Respectively was correlated with differentiation (t=3.31, P=0.002).Conclusion Higher expression of BCRP may play a major role in the intrinsic MDR of NSCLC, detection of BCRP expression may assist the guidance of individualized chemotherapy for patients with NSCLC.关键词
乳腺癌耐药蛋白/非小细胞肺癌/表达Key words
breast cancer resistance protein(BCRP) / non-small cell lung cancer(NSCLC) / expression分类
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吴玉竹,骆海军,王鹏,刘跃..非小细胞肺癌中BCRP mRNA表达的临床意义[J].现代检验医学杂志,2013,28(2):63-65,3.
