现代检验医学杂志2013，Vol.28Issue(2)：93-95,3.DOI:10.3969/j.issn.1671-7414.2013.02.028
酯溶性辅酶Q致突变性实验研究
Study on the Mutagenic Effect of the Liposolubility Coenzyme Q
摘要
Abstract
Objective To study the possibility of mutagenic and the genetic toxicity on the coenzyme Q.Methods With the treatment of different doses of the coenzyme Q,the effect of the mouse bone marrow cells micronucleus and sperm abnormalities was observed by micronucleus test and sperm shape abnormality test.Through Ames test,the reverse mutation of four strains Salmonella typhimurium (TA97,TA98 ,TA100, TA102) was observed, with the treatment of different doses of the coenzyme Q.Results The bone marrow cells micronucleus rate and sperm deformity rate of mice treated with 2.5~10.0 g/ kg BW the coenzyme Q was not significant increase,there were not significant difference compared with the corresponding control group (P>0.05).Under the conditions of with and without metabolic activation system, the reverse mutation rate of four strains Salmonella typhimurium (TA97 ,TA98,TA100,TA102) was not significant increase up to 5 000 ug/plate,compared with the control group,no significant difference (P>0.05).Conclusion It was not found the direct or indirect mutagenic effect and the genetic toxicity associate with the coenzyme Q.关键词
辅酶Q/遗传毒性/精子畸形Key words
coenzyme Q/genetic toxicity/sperm abnormalities分类
医药卫生引用本文复制引用
李志,杨颖,张静,陈秀绢,黄俊明..酯溶性辅酶Q致突变性实验研究[J].现代检验医学杂志,2013,28(2):93-95,3.基金项目
广东省医学科学技术研究基金资助项目(A2010058). （A2010058）
