摘要
Abstract
Objective To explore the diagnostic significance of serum CTGF,cystatin C (Gys C) , and urine β2-MG detection in the early stage renal damage in Diabetes.Methods June 2009~June 2011, According to urinary albumin excretion rate (UAER),94 cases diabetic patients were divided into 3 groups.A group was 32 cases of patients with microalbuminuria (UAER<20 μg/min) ,B Group was 31 cases of patients with substantial proteinuria (UAER20~200 μg/min) ,C group was 31 cases of patients with microalbuminuria (UAER>200 μg/min) , while the contral group was 30 healthy persons without diabetes.Serum CTGF,Cystatin C,and urine β2-MG were measured in each group.Evaluated the various indicators by Pearson's correlation analysis and ROC curve analysis.Results In patients with diabetic nephropathy,CTGF,Cys C and β2-MG on average were higher than that in patients without diabetes (P<0.05) ,and they were higher in B and C group than that in A group(P<0.05).In DM patients,CTGF,Cys-C and β2-MG was positively correlated with UAER (r=0.81,0.34,0.41, P<0.05).ROC areas of combined examination were more than every one.Conclusion CTGF, Cys-C and β2-MG were the sensitive indicators to diagnosis early stage clinical diabetic nephmpathy.Combined examination can have more practical value.关键词
结缔组织生长因子/胱抑素C/尿β2-MG/糖尿病肾病/早期诊断Key words
transforming growth factor/cystatin C/urine β2 MG/diabetic nephropathy/ early diagnosis分类
医药卫生
