西安交通大学学报（医学版）2013，Vol.34Issue(3)：366-370,5.
人脑胶质瘤p53、p15、VEGF的表达及与恶性程度的相关分析
Expressions of p53, p15 and VEGF in human brain glioma and their relationship with malignance degree
曾冉 1况建国 2邓世钢 3夏亮 2邓圣泽 2徐奖 1杨全喜 1公茂田1
作者信息
- 1. 南昌大学医学院研究生院,江西南昌 330006
- 2. 南昌大学第一附属医院神经外科,江西南昌 330006
- 3. 永修县人民医院,江西九江330300
- 折叠
摘要
Abstract
Objective To study the expressions of p53, p15 and vascular endothelial growth factor (VEGF) protein in human brain glioma and their relationship with pathological staging. Methods We chose 50 cases of gliomas of different pathological staging, including 20 cases of Grade Ⅱ glioma, 17 cases of Grade Ⅱ and 13 cases of Grade Ⅳ. Expressions of p53, p15 and VEGF protein were determined by immunohistochemical method. Results Expressions of VEGF and p53 were upregulated while the expression of p15 was downregulated with the increase of glioma pathological grading. In Grade Ⅱ to Ⅳ gliomas, the positive rate of p53 was 30%(6/20), 52. 9% (9/17) and 76. 9% (10/13); that of pl5 was 70% (14/20), 52. 9% (9/17) and 23. 1% (3/13); that of VEGF was 45% (9/20), 70. 6% (12/17) and 86. 7% (12/13). The expressions of p53 (r = 0.374), pl5 (r=-0.364) and VEGF 0 = 0.402) protein were significantly associated with pathological staging of gliomas (P<0.05). The positive rate of p53 and pl5 was 18.0%(9/50), that of p53 and VEGF was 44.0% (22/50), and that of p15 and VEGF was 26% (13/50). Significant correlation was found between p53 and pl5 (r= — 0.320), p53 and VEGF 0 = 0.464), and pl5 and VEGF (r = —0.352) (P<0.05). Conclusion Expressions of p53, pl5 and VEGF protein are important indicators for judging the biological behavior of gliomas. THcy are closely related to the occurrence and development of gliomas, and tHcy synergize one another, jointly promoting the proliferation of tumor cells and the formation of new blood vessels.关键词
胶质瘤/p53蛋白/p15蛋白/血管内皮生长因子(VEGF)/免疫组化Key words
glioma/ p53 protein/ p15 protein/ vascular endothelial growth factor(VEGF)/ immunohistochemistry分类
医药卫生引用本文复制引用
曾冉,况建国,邓世钢,夏亮,邓圣泽,徐奖,杨全喜,公茂田..人脑胶质瘤p53、p15、VEGF的表达及与恶性程度的相关分析[J].西安交通大学学报（医学版）,2013,34(3):366-370,5.
