新医学2013，Vol.44Issue(1)：65-67,3.DOI:10.3969/g.issn.0253-9802.2013.01.020
辛伐他汀对缺血性心力衰竭大鼠脑钠肽及射血分数的影响
Effects of simvastatin on BNP and EF levels in rats with ischemic heart failure
张慧珠1
作者信息
- 1. 510100广州,广东省医学科学院广东省人民医院,广东省老年医学研究所重症监护病房
- 折叠
摘要
Abstract
Objective: To investigate the effects of 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) re-ductase inhibitors simvastatin on brain natriuretic peptide (BNP) and ejection fraction (EF) , in rats with ischemic heart failure. Methods: Healthy male SD rats with postoperative heart failure after surgery, were randomly selected and divided into control group and statin group, and eight healthy male SD rats were selected as sham group. Simvastatin was given 5 mg/ (kg · d) in stain group, while pure water was given in other groups. After 4 weeks of intragastric administration treatment, serum BNP concentration detection and EF measurement via ultrasound. Results: After 4 weeks, the BNP levels incresed in stain group and control gorup, meanwhile EF decreased, and the differences were statistical significance among three groups (P < 0. 05). The level of serum BNP in statin group was lower and EF higher than those in control group. Serum BNP levels and EF showed a negative correlation (r = -0. 71, P <0. 01). Serum BNP concentration of heart failure were reduced with ejection fraction increased. Conclusion: Rats with ischemic heart failure received simvastatin treatment can significantly improve heart function.关键词
缺血性心力衰竭/辛伐他汀/脑钠肽/射血分数Key words
Ischemic heart failure/ Simvastatin/ Brain natriuretic peptide/ Ejection fraction引用本文复制引用
张慧珠..辛伐他汀对缺血性心力衰竭大鼠脑钠肽及射血分数的影响[J].新医学,2013,44(1):65-67,3.
