中国药房2013，Vol.24Issue(16)：1473-1477,5.DOI:10.6039/j.issn.1001-0408.2013.16.08
醒脑静注射液辅助治疗病毒性脑炎疗效及安全性的Meta分析
Meta-analysis of Therapeutic Efficacy and Safety of Xingnaojing Injection for Adjuvant Therapy of Viral Encephalitis
摘要
Abstract
OBJECTIVE: To evaluate the therapeutic efficacy and safety of Xingnaojing (XNJ) injection for adjuvant therapy of viral encephalitis. METHODS: Retrieved from Pubmed, EMbase, Cochrane Library, CBM, CNKI and Wanfang database, RCTs about XNJ injection for adjuvant therapy of viral encephalitis were collected. After evaluating quality and extracting data, Rev Man 5.0 software was used for Meta-analysis. RESULTS: A total of 14 RCTs were included, involving 1 114 patients. Results of Meta-analysis showed: compared with control group, XNJ injection could improved cure rate significantly [children: OR=3.18, 95%CI (2.28,4.44), P<0.01, adult: OR=3.26, 95%CI( 1.29,8.23), P=0.01], and shortened the time of fever fadeaway [MD= -1.97, 95%CI( -2.43, -1.51), P<0.01], headache disappearance[MD=-1.86, 95%CI( -2.58, - 1.14) ,P<0.01], stopping vomiting [MD= -0.76, 95%CI( -1.08,-0.43), P<0.01], stopping convulsions and consciousness [MD= -1.51, 95%CI ( -2.20, -0.82) , P<0.01], disorders recovery[MD=- 1.57, 95%CI( -2.38, -0.76) ,P<0.01]; there was statistical significance. There was no significant difference in incidence of ADR between XNJ group and control group[OR=0.86, 95%CI (0.41, 1.82) ,P=0.69]. CONCLUSION: Current evidences show that XNJ can increase curative rate and improve clinical symptoms and signs of patients with viral encephalitis compared to control group. However, further clinical trials should be carried out to evaluate its long-term effectiveness.关键词
醒脑静注射液/病毒性脑炎/Meta分析Key words
Xingnaojing injection/ Viral encephalitis/ Meta-analysis分类
医药卫生引用本文复制引用
何忠芳,武新安,王燕萍,鲁雅琴,梁莉,王晓华..醒脑静注射液辅助治疗病毒性脑炎疗效及安全性的Meta分析[J].中国药房,2013,24(16):1473-1477,5.基金项目
甘肃省科技计划立项项目(No.1107RJZA238) （No.1107RJZA238）
