北京生物医学工程2012，Vol.31Issue(6)：652-656,5.DOI:10.3969/j.issn.1002-3208.2012.06.23
RNA二级结构在siRNA设计中的应用
Application of RNA secondary structure in siRNA design
桂坚斌 1孙迎 1高武1
作者信息
- 1. 上海理工大学医疗器械与食品学院,上海200093
- 折叠
摘要
Abstract
RNA interference (RNAi) is a kind of gene silencing. Small interfering RNA (siRNA) is used to suppress gene expression by degrading the message RNA (mRNA) of the target gene. Effective siRNAs are important in RNAi experiments. There are a lot of principles for siRNA design,such as MPI basic principles and Tuschl principles and so on. On the basis of these studies, some have made further research on the relationship between RNA secondary structure and silencing efficiency of siRNA,and several models have been established,such as H-b index,spelling loops and so on. In this paper,we discuss and analyze the studies of RNA secondary structure in siRNA design.
关键词
RNA干扰/二级结构/siRNA/沉默效率Key words
RNAi/secondary structure/siRNA/silencing efficiency分类
医药卫生引用本文复制引用
桂坚斌,孙迎,高武..RNA二级结构在siRNA设计中的应用[J].北京生物医学工程,2012,31(6):652-656,5.
