重庆医学2013，Vol.42Issue(15)：1692-1695,4.DOI:10.3969/j.issn.1671-8348.2013.15.004
骨形成蛋白-2在上颌骨快速牵引骨愈合中的作用
Effect of bone morphogenetic protein-2 on bone healing in supramaxillary fast traction
摘要
Abstract
Objective To investigate the effect of adding recombinant human bone morphogenetic protein-2 (rhBMP-2 ) on the bone regeneration in sutural supramaxillary distraction osteogenesis (elasticity traction force> 800 g) .Methods 36 healthy hybrid dogs were randomly divided into 5 groups ,control ,400 g ,600 g ,800 g and 800 g+rhBMP-2 (combined) groups ,and killed in postoperative 1-8 weeks for X-ray examination and immunohistology staining .Results Supramaxilla was successfully moved forward in the various traction groups especially in the 600 g group(25.3±5 .2)mm .The traction speed in the 800 g group was fast within 2 weeks and significantly slowed after 4 weeks(12 .1±2 .3)mm ,which was improved after injection of rhBMP-2[(24 .2±3 .4)mm] . Immunohistochemical staining showed that the positive staining of BM P -2 ,BM P-4 and BM P-7 was evident in osteoblast plasma .After injection of rhBMP-2 ,the light density value in BMP-7 was obviously enhanced .The CT examinations showed that the bone density values in jawbone horizontal plate was significantly decreased especially in the 800 g group[(317 .8±185 .5)HU],but after injection of rhBMP-2 ,which was significantly enhanced[(1 158 .0±93 .0)HU ].Conclusion Sutural traction for advancing supramaxilla can extend the bone length at the early stage of microtrauma .RhBMP-2 may play certain role in the bone formation and the regulation of the activity of BMP-7 .关键词
骨整合/牵引术/骨生成/重组人骨形成蛋白-2Key words
osseointegration/t raction / osteogenesis/ recombinant human bone morphogenetic protein-2引用本文复制引用
姚玉胜,王程越,王桂君..骨形成蛋白-2在上颌骨快速牵引骨愈合中的作用[J].重庆医学,2013,42(15):1692-1695,4.基金项目
辽宁省教育厅及辽宁医学院博士启动基金资助项目(L2010281). （L2010281）
