郑州大学学报（医学版）2013，Vol.48Issue(3)：327-330,4.DOI:10.3969/j.issn.1671-6825.2013.03.009
白藜芦醇对铅暴露小鼠学习记忆能力及氧化应激相关因子的影响
Effects of resveratrol on learning memory performance and oxidative stress in lead exposure mice
摘要
Abstract
Aim:To explore the effects of resveratrol (RES) on the learning memory performance and oxidative stress in lead exposure mice.Methods: Fifty Kunming mice were randomly divided into five groups , which were control group , lead exposure only group (Pb) , low ( L) , middle ( M) , and high ( H) dose RES interfering groups.The mice were allowed freely to drink water.After eight weeks feeding , Morris water maze (MWM) test was employed to evaluate the leam -ing memory ability of the mice.The lead levels in blood and hippocampus were analyzed by graphite furnace atomic absoip -tion spectrometry.Serum and hippocampal SOD activity and MDA level were measured .Results: MWM test showed that the escape latency among the 5 groups had significant differences (F=9.044 , P < 0.001 ).The lead levels in blood and hippocampus had significant differences (F = 24.142 and 17.511 ,P <0.001).Compared with Pb group ,the lead levels in hippocampus of RES interfering groups reduced ( P < 0.05 ).The SOD activity in blood and hippocampus showed signifi -cant differences among groups (F=35.190 and 11.933,P <0.001).The MDA levels also showed significant differences among groups (F=5.610 and 4.406,P <0.05).Compared with control group,the serum and hippocampal SOD activity significantly decreased in Pb group and the three RES interfering groups (P <0.05).Compared with Pb group,the SOD activity in M and H groups significantly increased (P < 0.05).Conclusion: RES could reduce the lead levels in blood and hippocampus , reverse the learning memory damage in lead exposure mice , as well as increase SOD activity and reduce the level of MDA.关键词
白藜芦醇/铅暴露/氧化应激/小鼠Key words
resveratrol/ lead exposure / oxidative stress / mouse分类
医药卫生引用本文复制引用
李莹,张楠,刘芳丽,王雯,陈灿映,李文杰..白藜芦醇对铅暴露小鼠学习记忆能力及氧化应激相关因子的影响[J].郑州大学学报（医学版）,2013,48(3):327-330,4.基金项目
国家自然科学基金资助项目 81172716 （）
