李娜 1苗聪秀 1关素萍 1毕慧玲 1韩丽娟 1刘锦宏1
作者信息
- 1. 长治医学院附属和平医院生殖中心,长治,046000
- 折叠
摘要
Abstract
Aim:To explore the high risk factors in frozen embryo transplantation failure .Methods: The related data of 328 patients who accepted frozen embryo transplantation were retrospectively analyzed .Patients were divided into pregnancy group ( n = 107 ) and non-pregnancy group ( n - 221).Age, duration of infertility , causes of infertility , frozen meth- od, embryonic development time , embryo grade , endometrial preparation method , endometrial thickness , hormone level (estrogen/progesterone, E2/P) , insemination way, and transplantation position (DA/DB) were analyzed.The high risk factors were screened using logistic regression model.Results: The differences of age (t = 3.908, P < 0.001 ) , frozen method(χ2= 10.239 , P < 0.001 ) , embryo grade (χ2 = 9.853, P = 0.002 ) , endometrial thickness (χ2= 77.556 , P < 0.001 ) , hormone level (χ2 = 39.265 , P < 0.001 ) and transplantation position (χ2 = 12.395 , P = 0.002 ) between pregnancy group and non-pregnancy group were significant.Logistic regression analysis results displayed that age (P =0.026) , frozen method ( P = 0.005 ) , embryo grade ( P < 0.001) , endometrial thickness ( P = 0.026) were related to pregnancy out -come,and OR(95% CI) were 0.537 (0.310 - 0.929 ) ,0.472 (0.279 - 0.798 ) ,0.221 (0.108 - 0.455 ) and 0.654(0.451 -0.950).Conclusion: Advanced age, poor embryo quality and bad endometrial receptivity are the independenthigh risk factors which lead to the failure of frozen embryo transplantation.关键词
冷冻胚胎/高危因素/logistic回归分析Key words
frozen embryo / high risk factor/ logistic regression analysis分类
医药卫生
