军事医学2013，Vol.37Issue(5)：372-375,4.DOI:10.7644/j.issn.1674-9960.2013.05.00
SQ109合成工艺改进
Improved synthesis of SQ109
摘要
Abstract
Objective To improve the synthesis process of N -geranyl-N'-(2-aclamantyl) ethane4 ,2-diamine( SQ109 ) and establish a cost-effective and effecient synthetic route. Methods Geraniol reacted with SOC12 to produce intermediate 2,2 ,1-chloro-3 ,7-dimethyl-2,6-octadiene. The key intermediate 3, N'-(2-geranyl) ethane-1 ,2-diamine, was synthesized via reduction animation starting from intermediate 2. Then intermediate 3 reacted with 2-adamantanone by reduction amina-tion to obtain the target compound. Results and Conclusion The target compound was confirmed by 1H-NMR, LC-MS, and elemental analysis. The overall yeild was 66. 6% (based on geraniol). The advantage of this method lies in the cheap and easily-available raw materials , simple operation and high yield in each step.关键词
SQ109/抗结核药/磁共振波谱学/合成Key words
SQ109 / anti-tubercular drugs/ magnetic resonance spectroscopy / synthesis分类
医药卫生引用本文复制引用
萧红街,杨艺虹,张珩,钟武..SQ109合成工艺改进[J].军事医学,2013,37(5):372-375,4.基金项目
国家科技支撑计划资助项目(2011BAI18B01) （2011BAI18B01）
