临床与实验病理学杂志2013，Vol.29Issue(5)：497-501,5.
子宫内膜样腺癌MUC1表达及其与ER、PR表达的相关性
Expression of MUC1 and its correlation with the expression of ER and PR in endometrioid adenocarcinoma
摘要
Abstract
Purpose To investigate the expression of MUC1 in endometrioid adenocarcinoma and the relationship between with ER and PR. Methods The MUC1 protein were examined by immunohistochemistry ( Envision method ) in endometrioid adenocarcinoma ( n = 56 ), endometrial atypical hyperplasia ( n = 28 ) and proliferative endometrium ( n = 18 ). At the same time the ER alpha protein and PR protein were detected in endometrioid adenocarcinoma with same method. Results ( 1 ) In proliferative endometrium, endometrial atypical hyperplasia and endometrioid adenocarcinoma, the abnormal expression rate of MUC1 was 27. 8% , 71. 4% and 80. 4% , respectively and it was significant difference ( P = 0. 000 ). ( 2 ) In endometrioid adenocarcinoma, with the occurrence of menopause, histologic grade, stage enhancement and the muscle layer infiltration deepen, the abnormal expression rate of MUC1 protein have increased trends ( P > 0. 05 ). The positive rates of ER alpha and PR protein were related to histological grade ( P = 0. 003 , P = 0. 008 ), but they were not associated with mentrual status, muscle layer infitration, lymph node metastasis and stage ( P >0. 05 ). ( 3 ) In endometrioid adenocarcinoma, the expression of MUC1 protein has certain negative correlation relationship with ER alpha and has some positive correlation with PR, but they were not close correlation ( P >0. 05 ). Conclusions The abnormal expression rate of MUC1 increases significantly in endometrioid adenocarcinoma. MUC1 and ER alpha, PR has certain mutual regulation relationship.关键词
子宫肿瘤/子宫内膜癌/跨膜型黏蛋白1/雌激素受体/孕激素受体Key words
uterine neoplasms/endometrial carcinoma/MUC1 /ERa/PR分类
医药卫生引用本文复制引用
赵时梅,罗宇,任传伟,史琳,张安文..子宫内膜样腺癌MUC1表达及其与ER、PR表达的相关性[J].临床与实验病理学杂志,2013,29(5):497-501,5.基金项目
广西壮族自治区教育厅科研项目(200911MS285),广西壮族自治区卫生厅自筹经费课题(Z2012600) （200911MS285）
