临床与实验病理学杂志2013，Vol.29Issue(5)：532-535,4.
骶骨脊索瘤55例临床病理和免疫表型分析
Analysis of clinicopathologic features and immunophenotype in 55 patients with chordoma
摘要
Abstract
Purpose To investigate the clinicopathologic features and the expression of CK, vimentin, S-100 and Ki-67 on patients with sacral chordoma. Methods 55 cases diagnosed as chordoma with available slides and clinical information, coded between 2007 and 2011, were retrieved from the our department of pathology. The expression of CK, vimentin, S-100 and Ki-67 were examined using immunohistochemistry. Results Of the 55 cases, 35 were primary and 20 were recurrent cases. The ratio of males to females is 2. 2 ? 1. The age ranged from 21 to 85 years ( median, 52. 8 years ). The majority of the tumor showed nodular growth pattern, focally with nests. The neoplasm were composed of physaliphorous cells and satellite-like cells. The tumor cells revealed mild to moderate atypia and the mitosis was rare. The focal necrosis was observed in a minority of cases. Immunohistochemistry was performed in 55 chordoma cases including 35 primary and 20 secondary cases. Immunohistochemical finding showed that the expression of CK, vimentin, S-100 were detected in 96. 4%( 53/55 ), 100%( 55/55 ), 94. 5%( 52/55 ) cases, respectively. The index of Ki-67 ranged from 2 to 25% . No significant difference between primary and secondary chordoma cases in the expression of CK, vimentin, S-100 and Ki-67 was found ( P > 0. 05 ). Conclusions The chordoma is a kind of low grade malignant tumor and susceptible to recurrence. The combination detection with CK, vimentin, S-100 and Ki-67 may be adjunct to pathologic diagnosis of chordoma.关键词
骶骨肿瘤/脊索瘤/病理诊断/免疫组织化学Key words
sacral neoplasms/chordoma/pathologic diagnosis/immunohistochemistry分类
医药卫生引用本文复制引用
张彤,陈云新,沈丹华,王颖,张银丽,陈定宝,宋秋静..骶骨脊索瘤55例临床病理和免疫表型分析[J].临床与实验病理学杂志,2013,29(5):532-535,4.基金项目
北京大学人民医院院内基金资助(RDC2011-01) （RDC2011-01）
