贾晓炜 1栾进 2张南雁 3李岚 1赵琳 1贾贺堂1
作者信息
- 1. 100091,北京,解放军309医院内分泌风湿免疫科
- 2. 102613,北京,武警部队疾病预防控制中心疾病控制科
- 3. 710032,西安,第四军医大学西京医院内分泌代谢科
- 折叠
摘要
Abstract
Objective To discuss the clinical implications of urinary β2 microglobulin(U - β2 - MG)and its related factors in T2 Diabetes Mellitus patients with diabetic nephropathy( DN). Methods We collected 171 diagnosed DN patients (male 109, female 62). Correlation analysis of U - β2 - MG and the other clinical test items was made. Correlation analysis was made again after we divided patients into three groups: simple DM , DM with hypertension, DM with hypertension and hyperlipidemia. Results Positive correlation between levels of U - β2 - MG and indices as A1 β, IgG, al - MG, level of SCr and SBP was found. Within group DM, levels of U - β2 - MG had an significantly positive correlation with levels of CHO、HDL、BUN, while showing negative correlation with GFR. In the group of DM with hypertension, there was a positive correlation with levels of U - β2 - MG and those of SBP,CHO,LDL, SCr, and a negative correlation with GFR . In the last group, there was an significantly positive correlation between levels of U - β2 -MG and DBP, LDL, BUN, and still a negative correlation with level of U - β2 - MG and GFR. Conclusions Damage of Tubule interstitial is easily found in DN patients. U - β2 - MG was negatively correlated with GFR, indicating that U - β2 - MG has already increased when GFR slightly decreased. The produce of U - β2 - MG is closely related to the level of blood glucose ,blood pressure, and lipid level. U - β2 - MG was significantly associated with CHO, LDL - C, SCr, which showed that early active control of blood lipid might have positive effects on the prognosis of DN, especially in aspect of avoiding renal tubular damage.关键词
2型糖尿病肾病/肾小管/相关分析Key words
type 2 diabetic nephropathy/ kidney tubule/ relevant analysis分类
医药卫生
