武警医学2013，Vol.24Issue(5)：422-424,3.
不同药物对创伤后应激障碍大鼠血浆促肾上腺皮质激素和皮质醇的影响
The Effect of Different Drugs on plasma ACTH and COR of rat with posttraumatic stress disorder
摘要
Abstract
Objective To explore the effects of ganmaidazao Decoction ( GMDZ Decoction) , zhizichi Decoction ( ZZC Decoction) and Gastrodine capsule on ACTH and COR in plasma of PTSD rats. Methods Forty male rats were divided into five groups: control group, model group, group of GMDZ Decoction, group of ZZC Decoction, group of Gastrodine. Using SPS animal model ,three drugs were fed for 14 days after SPS of rats. The plasm levels of ACTH, COR were detected by radioimmunoassay. Results The result showed that the plasm levels of ACTH, COR were significantly increase in SPS model of rats in comparison with control group ( P <0. 01). GMDZ Decoction, ZZC Decoction and Gastrodine could descend the contents of ACTH and COR, and there was no significant difference between three drug groups(P >0. 05) . Conclusions The drugs of GMDZ Decoction, ZZC Decoction and Gastrodine capsule can modulate the endocrine function disorder of PTSD rat.关键词
创伤后应激障碍/单一延长应激模型/下丘脑-垂体-肾上腺轴/促肾上腺皮质激素/皮质醇Key words
post - traumatic sress disorder/ single prolonged stress/ hypothalamic - pituitary - adrenal / adrenocorticotropic hormone/ cortisol分类
医药卫生引用本文复制引用
刘敏,袁红,陈金宏,郑春秀,张振文,梁立武,郑静晨..不同药物对创伤后应激障碍大鼠血浆促肾上腺皮质激素和皮质醇的影响[J].武警医学,2013,24(5):422-424,3.基金项目
卫生行业科研基金(201302003) （201302003）
