中国全科医学2013，Vol.16Issue(10)：1178-1180,3.DOI:10.3969/j.issn.1007-9572.2013.04.031
2008-2011年住院结核病患者下呼吸道感染病原体分布及耐药性分析
Distribution of Pathogen Causing Lower Respiratory Tract Infections in Tuberculosis Inpatients and Drug Resistance from 2008 to 2011
刘刚 1胡志东 2张丽霞 3张立2
作者信息
- 1. 300070,天津市,天津医科大学研究生院
- 2. 天津市海河医院检验科
- 3. 天津医科大学总医院医学检验科
- 折叠
摘要
Abstract
Objective To investigate the distribution characteristics and drug resistance of pathogenic bacteria causing lower respiratory tract infections in hospitalized patients with tuberculosis, so as to provide a scientific evidence for clinically reasonable use of antibiotics. Methods Sputum specimens from hospitalized tuberculosis patients from 2008 to 2011 were obtained for routine bacterial isolation and culture. The VITEK - 2 Compact automated microbial analyzer was used for identifying the isolated strains and for susceptibility testing. Results A total of 2 354 bacterial strains were isolated, in which Gram - negative bacilli accounted for 1 007 stains ( 42. 8% ), Gram - positive cocci accounted for 292 stains ( 12. 4% ), and fungi accounted for 1 055 stains ( 44. 8% ). Gram - negative bacilli of the top three were Klebsiella pneumoniae, Pseudomonas aeruginosa and Esch-erichia coli. The drug resistance rates of the first two to the majority of antibiotics were below 50% . ESBLs - producing strains in Escherichia coli accounted for more than 60% , but these strains were all sensitive to cefoperazone/sulbactam, imipenem and meropenem. Staphylococcus aureus ranked the first in Gram - positive cocci, of which MRSA accounted for more than 70% , being multiple drug - resistant strain. But no strains resistant to vancomycin, linezolid, and tigecycline were found. The main pathogens in fungi were Candida albicans and filamentous fungi, whose resistance rates to commonly used antifungal agents were below 30%. Conclusion The multi -drug resistance caused by ESBLs -producing strains in Escherichia coli, and MRSA, as well as the infection rate caused by gram - negative bacilli and fungi have been gradually increased, which should be taken seriously. The monitoring of clinical pathogens and their drug resistance should be strengthened. It is of great significance to use antibiotics rationally, control the infection of lower respiratory tract in tuberculosis patients effectively, and reduce the occurrence of resistant bacteria or retard their development.关键词
结核病/呼吸道感染/病原体/分布/耐药性Key words
Tuberculosis/ Respiratory tract infections/ Pathogen/ Distribution/ Drug resistance分类
医药卫生引用本文复制引用
刘刚,胡志东,张丽霞,张立..2008-2011年住院结核病患者下呼吸道感染病原体分布及耐药性分析[J].中国全科医学,2013,16(10):1178-1180,3.
