四川大学学报（医学版）2013，Vol.44Issue(2)：303-307,5.
丹酚酸B磷脂复合物自乳化药物传递系统的制备及质量评价
Optimization and Characterization of SalB-PC Loaded Self-emulsifying Drug Delivery System
童廷德 1黄蕊 1孙逊 1张彦 2龚涛 1张志荣1
作者信息
- 1. 四川大学华西药学院靶向药物与释药系统教育部重点实验室,成都610041
- 2. 重庆药友制药有限公司研发中心,重庆401121
- 折叠
摘要
Abstract
Objective To prepare self-emulsifying delivery system ( SEDDS) of Salvianolic acid B phospholipid complex (SalB-PC) and evaluate its quality. Methods The best formulation was optimized using single-factor and pseudo-ternary phase diagrams, according to the emulsifying efficiency, the characteristics and partical size of the emulsion and other indicators. The morphology, particle size, zeta-potential and the release in artificial intestinal fluid of self-emulsifying formulation were evaluated. Results The weight ratio of SalB-PC : Lauroglycol FCC : Cremophor EL ! Transcutol P in the best formulation was 9 : 45 : 40 : 15. SalB-PC loaded self-emulsifying formulation is yellow and transparent solution, with partical size about ( 187. 2 ± 7. 1 ) nm, polydispersity index (PDI) about 0. 267 ± 0. 008 and zeta-potential about ( — 35. 6 ± 2. 7) mV after diluted about 100-fold. The self-emulsifying formulation released slower than the solution with only SalB or SalB-PC. Conclusion Water-soluble drug Salvianolic acid B can be prepared to SEDDS, and this formulation can slow down the release of SalB in artificial intestinal fluid.关键词
水溶性药物/丹酚酸B/磷脂复合物/自乳化给药系统Key words
Water-soluble drug/Salvianolic acid B/Phospholipid complex/Self-emulsifying drug delivery systems引用本文复制引用
童廷德,黄蕊,孙逊,张彦,龚涛,张志荣..丹酚酸B磷脂复合物自乳化药物传递系统的制备及质量评价[J].四川大学学报（医学版）,2013,44(2):303-307,5.
