国际眼科杂志2013，Vol.13Issue(6)：1087-1089,3.DOI:10.3980/j.issn.1672-5123.2013.06.06
姜黄素及Avastin抑制鼠角膜碱烧伤新生血管对比
A comparison about the inhibitory effect of curcunmin and Avastin on the rat corneal neovascularization
摘要
Abstract
AIM: To compare the inhibitory effect of curcunmin and Avastin on the rat corneal neovascularization(CNV), and approach the mechanism of the curcunmin's inhibition.METHODS: CNV was established in thirty SD rats by alkaline burning. Rats were divided equally to group A and group B at random. In group A, right eyes were experimental group A1, treated by 40μmol/L curcunmin solution, and left eyes were control group A2, treated by 0. 09% sodium chloride. In group B, right eyes were experimental group group B1, treated by 5g/L avastin, and left eyes were control group B2, treated by 0. 09% sodium chloride. Cornea and aqueous humor were collected by time spot. The capillary vessels were study, and the expressions of VEGF were detected by Enzyme-Linked immunosorbnent Assay (ELISA).RESULTS: No toxic effects of the drugs were found. The capillary vessels in experimental group were less than those of control group (P<0. 01 ). No statistical different of the capillary vessels between two drugs were found. The expressions of VEGF in experimental group were less than those in control group (P<0. 01). The expressions of VEGF in B1 group were less than in group A1.CONCLUSION: The inhibitory effect to CNV of curcunmin and avastin have no statistical different in the experiment, but curcunmin has the less inhibitory effect to the expressions of VEGF than avastin. Curcunmin may have other mechanism in the inhibitory action on CNV.关键词
姜黄素/Avastin/角膜新生血管/血管内皮生长因子Key words
curcunmin/Avastin/Corneal neovascularization/ vascular endothelial growth factor引用本文复制引用
吴艺,廖文雄,陆守权,李金生,古爱平,李华..姜黄素及Avastin抑制鼠角膜碱烧伤新生血管对比[J].国际眼科杂志,2013,13(6):1087-1089,3.基金项目
2011年广东省中医药局建设中医药强省课题基金(No.20111105) （No.20111105）
