国际眼科杂志2013，Vol.13Issue(6)：1090-1092,3.DOI:10.3980/j.issn.1672-5123.2013.06.07
多西环素对碱烧伤大鼠角膜炎症细胞浸润的抑制作用
Doxycycline inhibits the infiltration of inflammatory cells in rat alkali burn corneas
摘要
Abstract
AIM: To investigate the inhibited effect of Doxycycline on the infiltration of inflammatory cells in rat alkali burn corneas.METHODS: Corneas of 32 SD rats were injured with 1 mol/L NaOH, then divided into two groups: control and doxycycline - treated. All agents were administered topically 4 times daily. Slit - lamp microscope was performed and inflammatory index was calculated at 3, 7, 14 and 21 days after injury. Then 4 rats were randomly sacrificed and each cornea was divided into two parts, one for histopathology, the other for ICAM - 1 ELISA assay.RESULTS:ln control group, the inflammatory index and the number of inflammatory cell was higher than the doxycycline-treated dramatically at all time points ( P< 0.05). Compared with control group, corneal ICAM - 1 expression decreased significantly in doxycycline-treated group at all time points( P < 0.05).CONCLUSION: Doxycycline may inhibit inflammatory cell infiltration by down-regulating ICAM-1 expression.关键词
多西环素/碱烧伤/角膜/炎症细胞Key words
Doxycycline/alkali burn/cornea/ inflammatory cells引用本文复制引用
赵静博,邹文进,付馨余..多西环素对碱烧伤大鼠角膜炎症细胞浸润的抑制作用[J].国际眼科杂志,2013,13(6):1090-1092,3.基金项目
国家自然科学基金(No.81160119) （No.81160119）
广西自然科学基金(No.2012GXNSFAA053107) （No.2012GXNSFAA053107）
广西高等学校立项科研项目(No.201204LX064) （No.201204LX064）
