医药导报2013，Vol.32Issue(6)：733-737,5.DOI:10.3870/yydb.2013.06.014
奥氮平致体质量增加与HTR2C受体基因-759C/T多态性的关联研究
Study of the Association Between Olanzapine-induced Weight Gain and the -759C/T Polymorphism of HTR2C Receptor Gene
摘要
Abstract
Objective To study the association between single nucleotide polymorphism of 5-hydroxytryptamine 2C (HTR2C) receptor gene-759C/T (rs3813929) and weight gain in patients with schizophrenia treated with olanzapine. Methods Monotherapy with olanzapine was given to 181 first-episode schizophrenia patients (92 males, 89 females) for 12 weeks. The body weight, serum levels of glucose, triglyceride and cholesterol were measured before and after the therapy, and body mass index (BMI) was calculated. PCR-RFLP was used to analyze the frequencies of HTR2C receptor gene-759C/T hemizygote and genotype. The correlation between hemizygote or genotype and the changes of BMI value was analyzed. Results There was an average increase in body weigh of (4. 33+4. 15) kg, or (7.1±6.3)% from the baseline with a range of 0-22 kg or 0% -38% . The average BMI value was increased by (1. 52± 1. 48) kg·( m2)-1 The frequency of mutant homozygote was 13.0% among the 92 male patients. The frequency of mutant homozygote and the mutant heterozygote was 0% and 29. 2% , respectively, among the 89 female patients. The patients with-759C/C wild type homozygote (female) and -759C hemizygote (male) had more weight gain after olanzapine treatment . Conclusion The HTR2C receptor gene-759C/T polymorphism might be associated with olanzapine-induced weight gain, and -759T potentially could be a protective factor to prevent excessive weight gain in schizophrenia patients treated with olanzapine.关键词
奥氮平/体质量增加/5-羟色胺/基因多态性Key words
Olanzapin/ Weight gain/ 5-hydroxytryptamine/ Gene polymorphism分类
医药卫生引用本文复制引用
刘伟忠,何红波,何震宇,黄惜妮,张敏玲,张杰,梅尚英,刘文宪..奥氮平致体质量增加与HTR2C受体基因-759C/T多态性的关联研究[J].医药导报,2013,32(6):733-737,5.基金项目
广东省科技计划立项资助项目(2010B031600180) （2010B031600180）
