中国全科医学2013，Vol.16Issue(14)：1581-1583,3.DOI:10.3969/j.issn.1007-9572.2013.05.041
高尔基体糖蛋白73、α-L-岩藻糖苷酶、甲胎蛋白单项检测与联合检测对原发性肝癌的诊断价值研究
The Clinical Value of Single and Combined Detection by Golgi Protein 73,α-L-Fucosidase,and α-Fetoprotein in the Diagnosis of Primary Hepatic Carcinoma
摘要
Abstract
Objective To explore the value of single and combined detection by Golgi Protein 73 ( GP73 ), α - L -fucosidase ( AFU ) and α - fetoprotein ( AFP ) in the diagnosis of primary hepatic carcinoma ( PHC ).Methods We included 80 patients with PHC who first visited our hospital between May and September 2011 into the PHC group, 65 patients with hepato-cirrhosis into the cirrhosis group, 54 patients with chronic viral hepatitis into the hepatitis group, and 50 healthy people into the control group.Enzyme - linked immunosorbent assay ( ELISA ) was used to determine the serum GP73 level of the subjects, im-munoturbidimetry to determine AFU level, and electrochemiluminescence assay to determine serum AFP level.ROC curves of single and combined detection of PHC by GP73, AFU, and AFP were plotted to calculate the area under ROC curve ( AUC ), sensitivity, and specificity.Results Significant differences were observed among the four groups in serum GP73, AFU, and AFP levels ( P < 0.001 ).The AUCs of single detection by GP73 , AFUC, and AFP were 0.804 [ 95% CI ( 0.746, 0.862 ) ], 0.798 [ 95% CI ( 0.739, 0.858)], and 0.797 [ 95% CI ( 0.731, 0.862)], respectively, no significant difference found ( P > 0.05 ).The single detection by GP73 had higher sensitivity ( 82.5% ) and lower specificity ( 63.3% ) than AFP ( 66.3% , x2 =4- 65; 88.7% , x2 =28.91; P <0.05 ).The sensitivity of single detection by AFU ( 73.8% ) was not significantly different from that of AFP ( 66.3 % , x2 = 0.89, P > 0.05 ), while the specificity of AFU (77.5% ) was lower than that of AFP ( 88.7% , x2 = 8.40, P < 0.05 ).The sensitivity of combined detection by GP73 + AFU and GP73 + AFU + AFP was 92.5% and 96.3% , respectively.Conclusion GP73 has high sensitivity and AFP has high specificity in single detection of PHC.Combined detection by GP73, AFU, and AFP can greatly improve the detection rate of PHC.关键词
肝肿瘤/高尔基体/α-L-岩藻糖苷酶/甲胎蛋白类/诊断Key words
Liver neoplasms/ Golgi apparatus/ alpha - L - Fucosidase/ alpha - Fetoproteins/ Diagnosis分类
医药卫生引用本文复制引用
肖蕾,毛睿,杨颖,张瑞丽,忙尼沙·阿不都拉,包永星..高尔基体糖蛋白73、α-L-岩藻糖苷酶、甲胎蛋白单项检测与联合检测对原发性肝癌的诊断价值研究[J].中国全科医学,2013,16(14):1581-1583,3.基金项目
新疆医科大学第一附属医院青年科研专项基金(2011QN17) （2011QN17）
吴阶平医学基金会临床科研专项资助基金(320.6799.1138) （320.6799.1138）
乌鲁木齐市感染与肿瘤重点实验室(培育基地)课题(H111313001) （培育基地）
乌鲁木齐市科技局应用项目(Y111310002) （Y111310002）
