中国全科医学2013，Vol.16Issue(14)：1593-1595,3.DOI:10.3969/j.issn.1007-9572.2013.05.044
原发性高血压患者合并抑郁与血浆同型半胱氨酸水平的相关性研究
Correlation of Plasma Homocysteine with Depression in Essential Hypertension Patients
摘要
Abstract
Objective To explore the correlation of depression with plasma homocysteine ( Hey ) in essential hypertension ( EH ) patients.Methods Depression were screened by Zung self - rating depression scale ( SDS ) and sublist of hospital anxiety and depression scale ( HAD ) in 163 EH patients ( 114 males and 52 females ) admitted to this hospital from August 2011 to June 2012.Hey level was determined by enzymatic cycling assay.Results There were totally 69 EH patients combined with depression ( 42.3% ), 31 had hyperhomocysteine ( HHcy ) in this study.When the patients were divided, according to whether combined with depression, into depressive and non - depressive groups, no significant difference was noted in age, body mass index ( BMI), hypertensive duration, grade of hypertension or combination rate of coronary heart disease ( CHD ) between 2 groups ( P >0.05 ), there was difference in gender, Hey level and HHcy incidence ( P <0.05 ).When the patients were divided , based on blood pressure ( BP ) level, into 3 groups, there was no difference in plasma Hey level between patients with different BP degrades ( P >0.05 ), there was in SDS score ( P < 0.05 ).Conclusion EH patients have a high incidence of depression and there is gender difference ( higher in females than in males ).HHcy incidence and plasma Hey level increase in EH patients combined with depression.关键词
原发性高血压/抑郁/高同种半胱氨酸血症Key words
Essential hypertension/ Depression/ Hyperhomocysteinemia分类
医药卫生引用本文复制引用
李映映,帕丽达·阿布来提,古丽扎尔·买买提明..原发性高血压患者合并抑郁与血浆同型半胱氨酸水平的相关性研究[J].中国全科医学,2013,16(14):1593-1595,3.基金项目
新疆维吾尔自治区自然科学基金项目(2011211A083) （2011211A083）
