中国全科医学2013，Vol.16Issue(14)：1596-1598,3.DOI:10.3969/j.issn.1007-9572.2013.05.045
戒烟时间对急性心肌梗死溶栓再通前后炎性因子的影响研究
Smoking Cessation Time Influencing Expression of Inflammatory Cytokines in AMI Patient before and after Thrombolytic Recanalization
摘要
Abstract
Objective To explore the effects of smoking cessation time on expressions of serum IL - 1, TNF - α and IL - 10 in patients with acute myocardial infarction ( AMI) before and after thrombolytic recanalization.Methods Sixty AMI patients admitted to Chengde Central Hospital from July 2010 to December 2011 were divided, based on their smoking information, into Groups A ( nonsmoking), B ( cessation time <5 years ), C ( cessation time ≥5 years ).Recombinant streptokinase was used to perform intravenous thrombolysis.Venous blood was collected before thrombolysis, at hours 12, 24 after, to detect IL -1 , IL - 10 by double -antibody sandwich ABC - ELISA method, TNF -α by radioimmunoassay.Results There was significant difference in TNF -α, IL-1, IL-10 between 3 groups before thrombolysis and at hours 12 , 24 after ( P < 0.05 ); Group B had higher levels than groups A, C ( P <0.001 ); No difference was noted between groups A and C ( P >0.05 ).The levels of TNF -α, IL-1, IL-10 were significantly higher at hours 12, 24 after thrombolysis than before in 3 groups ( P < 0.001 ), higher at hour 24 than at hour 12 after thrombolysis in group B ( P <0.001 ), but there was no difference between groups A and C ( P >0.05 ).Conclusion The time of smoking cessation affects the inflammatory cytokines expression in AMI patients before and after thrombolytic therapy.Patients having stopped smoking 5 years or more have lower inflammatory cytokines expression, their myocardial ischemia - reperfusion injuries are basically the same as those of non - smokers.关键词
戒烟/急性心肌梗死/溶栓再通/肿瘤坏死因子-α/白介素-1/白介素-10Key words
Smoking cessation/ Acute myocardial infarction/ Thromblytic recanalization/ Tumor necrosis factor - alpha/ Interleukin - 1/ Interleukin - 10分类
医药卫生引用本文复制引用
陈治国,檀立端,于海霞,陈慧君..戒烟时间对急性心肌梗死溶栓再通前后炎性因子的影响研究[J].中国全科医学,2013,16(14):1596-1598,3.基金项目
承德市科学技术研究与发展计划项目(201121005) （201121005）
