中国全科医学2013，Vol.16Issue(15)：1705-1707,3.DOI:10.3969/j.issn.1007-9572.2013.05.080
超敏C反应蛋白和同型半胱氨酸与早期糖尿病肾病的相关性研究
Correlation between Level of High Sensitivity C Reactive Protein,Homocysteine and Early Stage Diabetic Nephropathy
吴文静 1朱志扬 2范书英 1郑金刚1
作者信息
- 1. 100029北京市,卫生部中日友好医院心内科
- 2. 山东省济宁市中医院心内科
- 折叠
摘要
Abstract
Objective To investigate the relationship between the level of serum high sensitivity C reactive protein ( hs - CRP ), serum homocysteine ( Hcy ) and early stage diabetic nephropathy ( DN ) .Methods Ninety one patients diagnosed as type 2 diabetes mellitus at the first time in department of endocrinology of our hospital from 2010 to 2012 were enrolled, and were divided into diabetes mellitus group ( 48 cases ) and early DN group ( 43 cases ) according to urine albumin urinary albumin excretion rate ( UAER ) .Serum hs - CRP and serum Hcy were measured.Relationship between hs - CRP, Hcy and UAER were analyzed by Pearson correlation.Logistic regression was used to analyze risk factor of early stage type 2 DN.Results ( 1 ) Levels of hs - CRP and Hcy in early DN group were higher than those in diabetes mellitus group [ hs - CRP: ( 2.6 ± 1.4 ) mg/L vs.( 1.4 ± 1.1 ) mg/L; Hcy: ( 32.7 ±7.7 ) μmol/L vs.( 19.3 ±4.9 ) μmol/L; P <0.01 ] .( 2 ) Pearson correlation analysis showed that levels of hs - CRP and Hcy had positive relation with UAER ( r =0.535 , 0.758 ; P <0.01 ) .Hcy had positive relation with hs - CRP too ( r = 0.411 , P < 0.01 ) .( 3 ) Logistic regression revealed that the levels of HbA1c, hs - CRP and Hcy were independently correlated with the risk of early damage of kidney (β= 0.568 , 0.807 , 0.064; P = 0.019 , 0.013 , 0.000 ) .Conclusion Elevated levels of hs - CRP or Hcy might be an important risk factor for early renal damage of patients with type 2 diabetes.关键词
超敏C反应蛋白/同型半胱氨酸/糖尿病肾病/危险因素Key words
High sensitivity C reactive protein/ Homocysteine/ Diabetic nephropathies/ Risk factors分类
医药卫生引用本文复制引用
吴文静,朱志扬,范书英,郑金刚..超敏C反应蛋白和同型半胱氨酸与早期糖尿病肾病的相关性研究[J].中国全科医学,2013,16(15):1705-1707,3.
