摘要
Abstract
Objective To investigate the clinical features of Kawasaki disease ( KD ) patients combined with abnormal liver function and its relation with IVIG resistance.Methods 167 KD children admitted to our hospital from January 2008 to January 2012 were divided into abnormal liver function group ( 41 cases ) and normal liver function group ( 126 cases ) .The gender, age, pre - treatment duration of fever, hospitalization, ICU admission, IVIG non - response rate, the incidence of coronary artery abnormalities and coronary artery aneurysms, glutamate aminotransferase enzyme ( ALT ), aspartate aminotransferase trans-ferase enzyme ( AST ), gamma glutamyl transferase ( GGT ), albumin, total bilirubin, C - reactive protein, erythrocyte sedimentation rate ( ESR ), white blood cell count ( WBC ) and platelet count ( PLT ) were compared between the two groups, and the influencing factors for IVIG non - response rate were analyzed.Results There were no statistically significant differences between the two groups in gender, duration of hospitalization, ICU admission rate, the incidence of coronary artery abnormalities and coronary artery aneurysms, albumin, total bilirubin, C - reactive protein, ESR, WBC and PLT ( P > 0.05 ) .The difference between the two groups in age, pre - treatment duration of fever, IVIG non - response rate, ALT, AST and GGT, were statistically significant ( P < 0.05 ) .Multivariate logistic regression analysis showed that elevated total bilirubin and hypoproteine-mia on admission were the risk factors for IVIG resistance.Conclusion Abnormal liver function is frequently found in patients with acute KD, and it may be the risk factors of IVIG resistance.Hypoproteinemia and elevated total bilirubin are the risk factors for IVIG resistance.关键词
黏膜皮肤淋巴结综合征/肝功能损害/免疫球蛋白Key words
Mucocutaneous lymph node syndrome/ Abnormal liver function/ Immunoglobulin分类
医药卫生
