中国全科医学2013，Vol.16Issue(15)：1755-1758,4.DOI:10.3969/j.issn.1007-9572.2013.05.094
阿德福韦酯致低血磷性骨软化症二例诊治分析
Adefovir Dipivoxil Induced Hypophosphatemic Osteomalacia:Report of Two Cases
摘要
Abstract
Objective To investigate clinical manifestations, treatment and prognosis of adefovir dipivoxil ( ADV ) induced hypophosphatemic osteomalacia.Methods Data of 2 chronic hepatitis B patients who developed hypophosphatemic osteomalacia after long - term administration of ADV (10 mg/d ) were analyzed and pertinent literatures at home and abroad reviewed.Results The 2 patients administrated a low dose of ADV for 4, 6 years, respectively.Both developed generalized bone pain, difficult movement and other symptoms after 3 years of administration.By laboratory examination, serum phosphate level decreased, alkaline phosphatase increased.The clinical symptoms improved after supplement of active vitamin D and calcium, serum phosphate returned to normal.Conclusion ADV has nephrotoxicity, which is positively correlated with doses and medication time.Long - term administration can lead to hypophosphatemic osteomalacia.关键词
骨软化症/磷代谢障碍/阿德福韦酯/药物毒性Key words
Osteomalacia/ Phosphorus metabolism disorders/ Adefovir dipivoxil/ Drug toxicity分类
医药卫生引用本文复制引用
王霞,郑慧,章振林..阿德福韦酯致低血磷性骨软化症二例诊治分析[J].中国全科医学,2013,16(15):1755-1758,4.基金项目
国家自然科学基金(81070692,81170803) （81070692,81170803）
上海市科委重大科技专题攻关专项(10D221950100) （10D221950100）
上海市卫生局新百人优秀学科带头人培养计划(XBR2011014) （XBR2011014）
