中国医学装备2013，Vol.10Issue(6)：9-13,5.DOI:10.3969/J.ISSN.1672-8270.2013.06.003
动态磁敏感对比MRI血脑屏障通透性定量分析技术及其在胶质瘤诊断中的初步应用
Quantitative measurement of blood-brain barrier permeability with DSC-MRI and its primary application in diagnosis of gliomas
摘要
Abstract
Objective: To introduce the principles and methods of quantitative measurement of blood-brain barrier permeability with modified Tofts-Kermode model based on DSC-MRI and application in the differentiation of high-grade and low-grade gliomas. Methods: Blood-brain barrier permeability of both brain lesions and normal tissues from 12 patients with different grades of gliomas were analyzed quantitatively. Parameters(Ktrans, Vp, Kep) were calculated, analyzed statistically and parameter images were reconstructed. Results: Ktrans of high-grade gliomas was larger than that of low-grade gliomas(P=0.031), while no significant difference was found between Vp and KeP of gliomas with different grade(P=0.126, P=0.756). Ktrans was a valuable indicator for the differentiation of high-grade and low-grade gliomas. A sensitivity of 100% and specificity of 58.3% were acquired when Ktrans=0.0274. Ktrans and KeP of gliomas were significantly larger than those of normal brain tissues(P<0.05). Conclusion: Blood-brain barrier permeability can be analyzed quantitatively with DSC-MRI, which represents potential values in diagnosis of gliomas.关键词
磁共振灌注成像/血脑屏障/通透性/胶质瘤/定量分析Key words
MR-PWI/ Blood-brain barrier/ Permeability/ Glioma/ Quantitative measurement分类
医药卫生引用本文复制引用
陈蕾,韩鸿宾,张海龙,邱立城,许陆飞..动态磁敏感对比MRI血脑屏障通透性定量分析技术及其在胶质瘤诊断中的初步应用[J].中国医学装备,2013,10(6):9-13,5.基金项目
国家自然科学基金面上项目(30972811)"脑组织液流动性的MRI示踪诊断技术与机制研究" （30972811）
北京大学第三医院临床学科重点项目(YLZD08-14-02)"不同量级的运动测量及成像关键技术研究" （YLZD08-14-02）
