南方医科大学学报2013，Vol.33Issue(5)：631-634,4.DOI:10.3969/j.issn.1673-4254.2013.05.03
Epi-LASIK术中上皮瓣去留对术后角膜上皮下雾状混浊及泪液中TGF-β1的影响
Transforming growth factor-β1 level in tears and corneal haze formation following flap-on or flap-off Epi-LASIK
摘要
Abstract
Objective To observe the influence of flap-on or flap-off Epipolis laser in situ keratomileusis (epi-LASIK) on the release of transforming growth factor-β1 (TGF-β1) in tear fluid and corneal haze formation.Methods Thirty patients (60 eyes) with myopia underwent epi-LASIK surgery with epithelial flap repositioning (flap-on) in the right eyes and epithelial flap removal (flap-off) in the left eyes.The level of TGF-β1 in tears was measured preoperatively and on days 1,3,and 7 postoperatively.Corneal haze was graded at 1,3 and 6 months after surgery.Results The mean preoperative spherical equivalent refraction was-4.98±2.28 D (-2.50 to-7.25 D) in flap-on group and-5.20±4.02 D (-1.75 to-7.00 D) in flap-off group,showing no significant difference between the two groups (P=0.80).TGF-β1 levels in the tear fluid were similar in the two groups preoperatively (P=0.11) and at 1,3,and 7 days postoperatively (P=0.55,0.45,0.19,respectively).TGF-β1 levels in tears gradually decreased after the first postoperative day in both groups,but were still higher than the preoperative value till the 7th postoperative day.Corneal haze scores in the two groups were similar at 1 month (P=0.98),3 months (P=0.52),and 6 months (P=0.72) after the operation.Conclusion Flap-on and flap-off epi-LASIK surgeries do not differ significantly in postoperative TGF-β1 levels in the tear fluid or in the postoperative haze scores.TGF-β1 may play a role in corneal wound healing.关键词
Epi-LASIK/上皮瓣/转化生长因子β1/上皮下雾状混浊Key words
Epipolis laser in situ keratomileusis/ epithelial flap/ transforming growth factor-β1/ haze引用本文复制引用
陈静,陈艺,韩苏宁,邹玉平,邹秀兰..Epi-LASIK术中上皮瓣去留对术后角膜上皮下雾状混浊及泪液中TGF-β1的影响[J].南方医科大学学报,2013,33(5):631-634,4.基金项目
Supported by Medical Science Foundation of Guangdong Province (B2010249) （B2010249）
广东省医学科研基金(B2010249) （B2010249）
