医学分子生物学杂志2013，Vol.10Issue(2)：85-90,6.DOI:10.3870/j.issn.1672-8009.2013.02.005
雌激素受体基因多态性与慢性乙型肝炎易感性的相关性
Relationship between ERα and ERβ Gene Polymorphisms and Susceptibility to Chronic Hepatitis B
廖晓敏 1周细国 1石书凡 1曾静2
作者信息
- 1. 怀化市第一人民医院检验科,湖南省怀化市,418000
- 2. 怀化市第一人民医院体检中心,湖南省怀化市,418000
- 折叠
摘要
Abstract
Objective To examine the polymorphisms of ERa and ERβ genes and their association with susceptibility to chronic hepatitis B. Methods A total of 112 patients with chronic hepatitis B and 100 healthy controls were genotyped for ERα Pvu Ⅱ, ERα Xbα Ⅰ, ERβRsa Ⅰ and ERβAlu Ⅰ gene polymorphisms by using the polymERase chain reaction restriction fragment length polymorphism (PCR-RFLP) method. Results The results showed that there was a significant difference in the frequency distribution of ERa genes rather than ERβ genes between chronic hepati -tis B patients and healthy controls ( P < 0. 05 ) . Multivariate logistic regression analysis showed that the subjects carrying the ERa Pvu Ⅱ C/T genotype were at a 2-fold elevated risk for chronic hepatitis B (OR = 1.86, 95% CI: .077~3.213) compared to those carrying ERαPvu Ⅱ C/C. The subjects carrying the ERα Xba Ⅰ A/A genotype were at a 4-fold elevated risk for chronic hepatitis B ( OR = 4. 2 , 95 % CI: 2. 306 ~ 7. 457) compared to those carrying ERα Xba Ⅰ G/G. Conclusion The polymorphisms of ERα Pvu Ⅱ and ERα Xba Ⅰ genes instead of ERβ Rsa Ⅰ and ERβAlu Ⅰ genes are closely associated with susceptibility to chronic hepatitis B.关键词
雌激素受体-α/雌激素受体-β/慢性乙型肝炎/基因多态性Key words
ERα/ ERβ/ chronic hepatitis B / gene polymorphisms分类
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廖晓敏,周细国,石书凡,曾静..雌激素受体基因多态性与慢性乙型肝炎易感性的相关性[J].医学分子生物学杂志,2013,10(2):85-90,6.
