中国临床医学2012，Vol.19Issue(5)：457-458,2.
冠状动脉微栓塞后Toll样受体4的变化
Expression of Toll-Like Receptor 4 in Swine Coronary Microembolization Models
摘要
Abstract
Objective:To study the expression of Toll - like receptor 4 (TLR4) in swine coronary microembolization (CME) models. Methods:CME models were made by injection of inertia plastic microspheres (diameter 42μm) into left anterior descending coronary in swincs. TLR4 in myocardial tissues of anterior wall and posterior wall was detected using Western- blot and real - time polymerase chain reaction. Results: The TLR4 protein levels of anterior wall and posterior wall were (0. 46 ± 0. 02) and (0. 17 ± 0. 01) in study group, and those were (0. 17 ± 0. 01) and (0. 16 ± 0. 01) in control group. The TLR4 mRNA levels of anterior wall and posterior wall were (3. 14 ± 0. 05) and (1.17 ± 0. 02) in study group, and those were (1. 25 ± 0. 01) and (1.03 ± 0.03) in control group. The expression of TLR4 was significantly higher in the anterior wall than the posterior wall in study group; and there were no significant difference in the expression level of TLR4 among the anterior wall, posterior wall in control group and the posterior wall in study group. Conclusions: The expression of TLR4 is elevated in the affected myocardial tissue after CME.关键词
冠状动脉微栓塞/Toll样受体/重构Key words
Coronary microembolization/ Toll - like receptor/ Remodeling分类
医药卫生引用本文复制引用
常书福,马剑英,钱菊英,陈章炜,姚瑞明,葛均波..冠状动脉微栓塞后Toll样受体4的变化[J].中国临床医学,2012,19(5):457-458,2.基金项目
国家自然科学基金资助项目(编号:30671998、30901383) （编号:30671998、30901383）
