中国临床医学2012，Vol.19Issue(5)：470-472,3.
长期胆汁反流对大鼠胃黏膜的影响
Effects of Chronic Bile Reflux on the Gastric Mucosa of Rats
摘要
Abstract
Objective:To establish a rat model that could simulate the physiological bile reflux in human beings, and to study the pathological effects of chronic bile reflux on the mucosa of glandular stomach and forestomach in rats. Methods:The duodenum of 13 Sprague -Dawley rats were transected below the opening of the common bile duct, and gastrojejunostomy was performed at the greater curvature of the forestomach. After the rats showed bile reflux for 1 year, the pathological features of the glandular stomach and forestomach mucosa were studied. The effect of bile reflux on gastrin expression in the glandular sto - mach mucosa was also studied by using immunohistochemistry. Results: Chronic bile reflux caused significant hyperplasia and expansion of gastric gland in the glandular stomach. Dysplasia and canceration also developed, whereas ulcer and intestinal metaplasia were relatively rare. In the forestomach, the squamous epithelium showed significant hyperplasia and keratinization along with keratin pearls and keratocysts, while intestinal metaplasia was relatively rare, and no ulcers or tumorigenesis was observed. Chronic bile reflux significantly increased gastrin expression in the glandular stomach mucosa. Conclusion: Chronic bile reflux caused significant hyperplasia along with dysplasia and canceration of the glandular and squamous epithelium of the rat gastric mucosa, and that might be related to high gastrin expression in the glandular stomach. Intestinal metaplasia and ulcer were relatively rare.关键词
胆汁反流/胆汁/腺癌/肠化生/胃泌素Key words
Bile reflux/ Bile/ Adenocarcinoma/ Intestinal metaplasia/ Gastrin分类
医药卫生引用本文复制引用
王学伟,曹勤,唐剑敏..长期胆汁反流对大鼠胃黏膜的影响[J].中国临床医学,2012,19(5):470-472,3.基金项目
上海中医药大学附属普陀医院基金(编号:20075030A) （编号:20075030A）
