中国临床医学2012，Vol.19Issue(5)：496-499,4.
维持性血液透析患者红细胞体积分布宽度及相关影响因素研究
Status of Red Blood Cell Distribution Width in Hemodialysis Patients and the Related Factors
摘要
Abstract
Objective:To investigate the status of red blood cell distribution width (ROW) in hemodialysis (HD) patients and the related factors. Methods: This cross - sectional study was carried out in 356 HD patients(226 male and 130 female) with mean age of (59. 2 ± 14. 5) years and mean dialysis vintage of (64. 3 ± 42. 5) months from Jan 2012 to Mar 2010. Medical history were collected and parameters such as hemoglobin (Hb), RDW, serum electrolytes, high sensitivity C- reactive protein (hsCRP), serum albumin,pre - albumin, ferritin, transferrin saturation , parathyroid hormone (iPTH) and N - terminal brain natriuretic peptide (NT-proBNP) were measured before the mid - week hemodialysis. Serum creatinine and blood urea nitrogen were measured before and after hemodialysis and spKt/V was calculated. Results: The mean level of RDW was (15. 14 + 1.22)% (13. 0%~20. 4% , median 14. 9%) in all patients, of which 241 (67.7%) were abnormal. RDW in male group was significantly lower than that in female group [(15. 03. ±1.11)% vs (15. 33 ± 1. 39) % , P<0. 05]. Spearman correlation analysis showed that RDW was positively correlated with age(r = 0. 269, P<0. 001 ),dialysis vintage (r = 0. 1 16, P = 0. 033) , EPO dose(r = 0. 250, P<0. 001) , EPO/Hb ratio (r = 0. 214, P<0. 001 ) , hsCRP(r = 0. 335 , P = <0. 001) and NT - proBNP(r = 0. 133,P = 0. 027). RDW was negatively correlated with serum albumin(r = - 0. 241 ,P<(). 001 ) and pre - albumin(r = - 0. 334,P<0. 001). Multivariate linear regression model showed that RDW was independently associated with serum albumin and EPO dose (P<0. 01). Conclusions: Abnormality of RDW is common in hemodialysis patients, which may be related to age, dialysis vintage, nutrition status, inflammation, heart disease, EPO dose and response. Further studies are needed to estimate the predictive value of RDW in hemodialysis patients.关键词
红细胞体积分布宽度/血液透析/横断面调查/因素分析Key words
Red blood cell distribution width/ Hemodialysis/ Cross - sectional study/ Factor analysis分类
医药卫生引用本文复制引用
沈波,刘中华,邹建洲,徐少伟,徐磊,潘文志,滕杰,钟一红,丁小强..维持性血液透析患者红细胞体积分布宽度及相关影响因素研究[J].中国临床医学,2012,19(5):496-499,4.基金项目
上海市重大课题(编号:08DZ1900602) （编号:08DZ1900602）
教育部国家"211工程"重点学科建设项目(三期)(编号:211XK20) （三期）
