中国临床医学2012，Vol.19Issue(5)：514-515,2.
硝苯地平对妊娠期高血压病患者胰岛素抵抗的作用
Effect of Nifedipine on Insulin Resistance in Patients with Pregnancy-Induced Hypertension
摘要
Abstract
Objective:To study the effect of nifedipine on insulin resistance (IR) in patients with pregnancy- induced hyperten-sion(PlH). Methods:A prospective randomized controlled trial has been conducted. From August 2008 to June 2010, 143 patients with PIH were randomized into nifedipine group (n = 73) or control group (n= 70). The patients in nifedipine group received nifedipin 10 mg tid for 2 to 3 weeks, while patients in the control group were given labetalol 100mg bid for 2 to 3 weeks. Insulin resistance was determined by homeostasis model assessment of insulin resistance (HOMA- IR) index. Results: There were no significant differences in baseline characteristics between the two groups. Compared with baseline value, HOMA- IR index decreases were observed in both groups all P<0. 05. Moreover, the nifedipine group decreased more significantly than the control group [(0. 10 ± 0. 06) vs. )0. 07 ± 0. 05,P = 0. 002]. Conclusions: This study showed that nifedipine therapy can improve insulin resistance in PIH patients.关键词
妊娠期高血压病/胰岛素抵抗/硝苯地平Key words
Pregnancy - induced hypertension/ Insulin resistance/ Nifedipine分类
医药卫生引用本文复制引用
李红,赵欣,黄彩梅,周文娟,张洁..硝苯地平对妊娠期高血压病患者胰岛素抵抗的作用[J].中国临床医学,2012,19(5):514-515,2.基金项目
上海市普陀区科学技术委员会暨卫生系统自主创新科研资助重点项目(编号:2008-32-4) （编号:2008-32-4）
