摘要
Abstract
Objective:To observe the effects of different doses of dexmedetomidine on cardiovascular responses to tracheal extubation in order to find out the ideal dose of dexmedetomidine. Methods: Eighty American Society of Anesthesiologists (ASA) score Ⅰ to Ⅱ adult patients scheduled for under general anesthesia were randomly divided into four groups, and each group involved 20 patients. At 10 minutes before the end of surgery, patients were administered intravenous infusion of 10 mL 0. 9% sodium chloride solution in group A, dexmedetomidine at a dose of 0. 3 μg/kg in group B, dexmedetomidine at a dose of 0. 5 fig/kg in group C and dexmedetomidine at a dose of 0. 7 μg/kg in group D. Mean arterial pressure (MAP) and heart rate (HR) were recorded before operation, 1 min before the tracheal extubation, at tracheal extubation and 5 min, 10 min, 20 min and 30 min after tracheal extubation. The duration from the termination of anesthesia to full recovery of spontaneously breathing,eye opening response to instruction and tracheal extubation were recorded. Postoperative complications were also recorded. Results: At 1 min before tracheal extubation, the moment of tracheal extubation and 1 min after tracheal extubation, MAP and HR in group A and MAP in group B increased significantly compared with the baseline value before operation, but MAP and HR did not increase significantly in group C and group D. At 5 min, 10 min, 20 min and 30 min after tracheal extubation, MAP and HR in group C and group D decreased significantly compared with the baseline value (P<0. 05). The time of breathing recovery, eye opening, and extubation were longer in group D compared with group A, group B and group C (P<0. 05). The incidences of postoperative restlessness and cough were significanthy lower in group C and group D than those in group A (P<0. 05). The incidences of hypotension and bradycardia were higher in group D than those in the other three groups. Conclusions: Dexmedetomidine 0. 5 μg/kg may attenuate cardiovascular responses to tracheal extubation with few side effects and no influence on recovery time.关键词
右美托咪啶/拔管/心血管反应/苏醒/不同剂量Key words
Dexmedetomidine/ Tracheal extubation/ Cardiovascular responses/ Quality of recovery/ Different doses分类
医药卫生
