安徽农业科学2013，Vol.41Issue(11)：4722-4724,3.
原核生物硒蛋白的生物合成
Selenoprotein Biosynthesis in Prokaryotes
摘要
Abstract
Selenium,one trace essential element for many organisms including mammals,is closely related to human health.Imbalance of selenium distribution would result the marked variation in selenium contents of local foods which would lead to the selenosis and selenium deficiency in areas with high and low selenium contents,respectively.After reduction and activation,intracellular selenate could be converted into selenium phosphate,which could be further catalyzed by selenocysteine synthase (SelA) to conjugate with Ser-tRNAUGAsec forming Sec-tRNAUGAsec to complete the selenocysteine (Sec) synthesis on its tRNA.Directed by selenocysteine insertion sequence (SECIS) and the EF-TU like elongation factor,SelB which is strictly specific for Sec-tRNAUGAsec,Sec was then inserted into selenoproteins in ribosomes.Selenate reduction in prokaryote and mechanism of incorporation Sec into selenoprotein were summarized,and biological selenate detector based on mechanism of selenoprotein biosynthesis was also proposed.关键词
硒/硒蛋白/硒代半胱氨酸/生物检测器Key words
Selenium/ Selenoprotein/ Selenocysteine/ Biological detector分类
农业科技引用本文复制引用
沈林星,邱洋松,孙婧,邬丹妮,孙爱,张冰倩,马建辉,孙梅好..原核生物硒蛋白的生物合成[J].安徽农业科学,2013,41(11):4722-4724,3.基金项目
国家自然科学基金项目(No.30800019) （No.30800019）
浙江省自然科学基金项目(No.Y3090546) （No.Y3090546）
教育部留学归国科研启动基金 （）
2012年浙江省新苗人才计划资助. （）
