安徽医科大学学报2013，Vol.48Issue(5)：530-534,5.
新疆维吾尔族HLA-DQB1基因多态性与HBV感染结局的相关性
Association of HLA-DQB1 polymorphism with the outcome of hepatitis B virus infection in Uygur population of Xinjiang
摘要
Abstract
Objective To invest the associations of human leukocyte antigen-DQB1 polymorphism with the outcome of HBV infection and the replication of HBV in Uygur population of Xinjiang. Methods 110 chronic hepatitis B patients, 100 asymptomatic HBV carriers,80 patients with self-cimited HBV infection and 45 healthy individuals were included in our study. DQB1 genotyping was conducted with polymerase chain reaction-sequence specific primer( PCR-SSP ). The frequency distributions of genotype were analyzed, and the frequency of that in different replication of HBV was studied. Results ①the frequency of the DQB1 * 0201 allele in RHBC group was significantly higher than ASC group( 18. 75% vs 10. 50% ,χ2=5.959,P <0. 05,OR =2. 257 );② the frequency of the DQB1 * 0201 allele was significantly higher in the CHB group than in the ASC group( 17. 73% vs 10. 50% ,χ2= 5. 363 ,P <0. 05 , OR = 2. 066 ); ③the frequency of the DQB1 * 0301 allele in CHB group was significantly higher than ASC group( 26. 82% vs 16. 50% ,χ2 = 9. 062, P <0. 01 , OR = 2. 349 ); ④the frequency of DQB1 * 0303 allele in CHB group was significantly lower than ASC group( 19. 55% vs 31. 00% , χ2= 10.996, P < 0. 01 , OR = 0. 393 ); ⑤ the frequency of the DQB1 * 0201 allele had significant difference in high replication and low replica-tion( 17. 08% vs 10. 56% , χ2= 4.295 , P < 0. 05 , OR = 1. 939 ). Conclusion Alleles of HLA-DRB1 * 0201 are closely associated with HBV clearance, and DQB1 * 0301 allele could aggravate persistent infection of HBV. DQB1 * 0303 allele determines the susceptibility to ASC.关键词
乙型肝炎病毒/HLA-DQB1/维吾尔族Key words
HBV/ HLA-DQB1/ Uygur分类
医药卫生引用本文复制引用
梁军,张永萍,杨晓筠,张艳君,仲英娜..新疆维吾尔族HLA-DQB1基因多态性与HBV感染结局的相关性[J].安徽医科大学学报,2013,48(5):530-534,5.基金项目
新疆维吾尔自治区人民医院院内科研项目(编号:20100105) （编号:20100105）
